PHE5015 Week 5 Assignment 1 Discussion Answer

Assignment 1: Discussion Questions

The instructor will assign you one question from the discussion questions listed below. Check the appropriate Discussion Area to see which question has been assigned. By Friday, September 29, 2017, respond to the assigned discussion question and submit your response to the appropriate topic in this Discussion Area.

Respond to the assigned question using the lessons and vocabulary found in the reading. Support your response with examples and research. Your response should clarify your understanding of the topic. It should be your own—original and free from plagiarism. Follow APA format for writing style, spelling and grammar, and citation of sources.

Start reviewing and responding to the postings of your classmates as early in the week as possible. Respond to at least two of your classmates. Participate in the discussion by analyzing each response for completeness and accuracy and by suggesting specific additions or clarifications for improving the discussion question response.

The STEP Study is the name of a clinical trial to test an experimental human immunodeficiency virus (HIV) vaccine that aimed to stimulate production of immune system T cells that can kill HIV-infected cells. The study enrolled 3,000 participants at sites in Australia, Brazil, Canada, the Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, and the United States.

On the basis of its first evaluation of vaccine efficacy, the findings were as follows:

  • There were 24 cases of HIV infection among the 741 volunteers who received at least one dose of the investigational vaccine.
  • There were 21 cases of HIV infection among the 762 volunteers who were vaccinated with a placebo.
  • In volunteers who received at least two vaccinations:
    • There were 19 cases of HIV infection among the 672 volunteers who received the investigational vaccine.
    • There were 11 cases of HIV infection among the 691 volunteers who received the placebo.

The investigators of the vaccine trials have decided to cease immunizations and are contacting study volunteers to inform them of the developments.

Prior to beginning this study, how would you have described the risks and benefits of the study to participants? Share your thoughts and discuss the ethical issues surrounding this study at the beginning and at the time the decision was made to terminate the study.

Justify your response using examples and reasoning. Comment on the postings of at least two classmates, explaining whether you agree or disagree with their views.


National Institutes of Health (2007). Immunizations are discontinued in two HIV vaccine trials. Retrieved from

Evaluation Criteria:

  • Provided at least one risk and one benefit.
  • Discussed at least two ethical issues at the beginning and two ethical issues at the end of the study.
  • Justified answers with appropriate research and reasoning by using examples and references from textbooks, the South University Online Library, and other acceptable references, citing the sources in APA format.
  • Commented on the postings of at least two classmates by asking questions, providing a point of view with a rationale, challenging a point of the discussion, or making a relationship between two or more points.
Assignment 1 Grading Criteria
Maximum Points
Quality of initial posting.
Frequency of responses to classmates.
Quality of responses to classmates.
Reference to supporting readings.
Language and grammar.
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